A schizophrenia-related genetic mutation alters cellular differentiation.

In Brain Disorders, Brain Science, Genetics by Brainy Days Ahead

A new study conducted by researchers in Japan finds that patients with schizophrenia carry a genetic mutation that alters the ratio of the different types of nerve cells they produce. The findings revealed abnormal differentiation in the neurospheres derived from the schizophrenic patients. They formed significantly fewer neurons, and significantly more astrocytes, than the neurospheres derived from the healthy control group. Also, neurons in the patients’ neurospheres migrated shorter distances than those derived from the healthy controls and also had significantly shorter fibers.