A recent article Nutritional supplements can enhance effectiveness of antidepressants describes research findings that certain nutritional supplements can increase the effectiveness of antidepressants for people with clinical depression. Among these supplements is S-adenosylmethionine (SAMe). The University of Melbourne research team also found good evidence for SAMe as a mood enhancing therapy when taken with antidepressants. Hundreds of millions of people worldwide currently take antidepressants. The researchers conclude, “There’s real potential here to improve the mental health of people who have an inadequate response to them.” SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine. In addition to the study quoted above, SAMe’s effectiveness has been proven in numerous previously published human trials.