Enzymes Guide Formation, Spread Of Brain Tumors.

In Brain Cancer, Brain Science, DNA, Genetics by Brainy Days Ahead

Enzymes are key to how brain cancer tumors form and spread. Researchers at The University of Texas MD Anderson Cancer Center reveal in a study that the enzymes Gen5 and alpha-KGDH induce hisrone succinylation and promote tumor cell proliferation and tumor development. Histones are gene-regulating proteins that play a central role in processes like the replication, transcription, and repair of DNA.  Succinylation is newly-identified histone modification process.  The researchers demonstrate that alpha-KGDH interacts with Gcn5 in the cell nucleus and that tumor cell proliferation and tumor growth were inhibited when alpha-KGDH was blocked from entering the cell nucleus or by disruption of Gcn5’s binding to succinyl-coenzyme A. Their finding illuminates how brain cancers grow and will propel future research using the knowledge to restrict the spread of cancers in the brain.