Fat Metabolism Averts Brain Damage Due To Aging.

In Alzheimer's, Brain Disorders, Brain Science by Brainy Days Ahead

Fat intake plus carbohydrates is shown in new research to prevent age-related diseases and promote healthy aging. Researchers at Aarhus University in Denmark have discovered an important piece of the puzzle. They determine that the fat-metabolism in our cells takes place simultaneously with a detoxification of the harmful substances in our blood sugar. It is these harmful substances that can lead to age-related diseases such as diabetes, Alzheimer’s and cancer. Their discovery means that we have a detoxification system that we were previously not aware of. Further, the researchers find that the detoxification system operates through a chemical process without the involvement of the enzymes that scientists have up until now focused on in seeking to understand our metabolism and untilization of sugar. The new research finds that a metabolite originating from the body’s fat-metabolism, called the ketone acetoacetate, captures and inhibits a second type of metabolite, methylglyoxal, which originates from the body’s sugar metabolism. Methylglyoxal is a reactive metabolite, being toxic for the cells. As such, it plays a major role in age-related diseases. For example, untreated diabetics have increased concentrations of sugars and methylglyoxal in their blood and also have increased amounts of ketone substances. The chemistery of what happens between the two metabolites is that a third metabolite, 3-HHD, emerges, which does not have the harmful effects of methylglyoxal. The Danish research team are the first to find 3-HHD in blood from people who lacked insulin and/or had fasted the night before – a condition known to give ketosis. The results suggest a diet higher in fat than carbohydrates may be especially important to diabetics and will keep us all healthier – and brainer – longer.