Mild brain trauma – will it lead to serious long-term effects? Researchers at UC San Francisco have developed an analysis and method for using fMRI (functional MRI) observations to highlight abnormal patterns of brain activity that predicted a higher risk for long-term, post-concussive symptoms. The study revealed telltale patterns of brain activity that, six months later, were associated with worse performance on behavioral and cognitive tests and were different from patterns seen in healthy control subjects. The 44 study participants had no evidence of bleeding or bruising in the brain in the immediate aftermath of their brain traumas according to computed tomography (CT) or ordinary MRI scans at the time of the injuries. The research means that physicians examining new injuries may now be able to predict which patients are more likely to continue experiencing symptoms months or years after the head-injury event.