RNA modification affects nervous system.

In Brain Development, Brain Disorders, Brain Science, Genetics, RNA by Brainy Days Ahead

Researchers at the Institute of Molecular Biology (IMB) and Johannes Gutenberg University Mainz (JGU)  show that an RNA modification (m6A) occurs at high levels in a developing fly’s nervous system and is important for this system to function. When researchers disrupted the molecular pathway that modifies the RNA, the flies had problems folding their wings correctly, could not orientate themselves anymore, and moved more slowly than flies whose RNA modifications were normal. These effects resulted from an impaired function of the brain. The m6A also was found to be important to fine-tune sex determination as male or female.