Separating pain relief from addiction.

In Brain Circuitry, Brain Disorders, Brain General Structure and Function, Brain Science, Senses and Perception by Brainy Days Ahead

Scientists and physicians alike are trying to develop tools to separate the analgesic (pain relief) actions of opioids from their addiction-related effects. Scientists at the Icahn School of Medicine at Mount Sinai have found that a key signaling protein in the brain known as RGS9-2 plays a critical role in the development of addiction-related behaviors. The protein acts as a positive modulator of oxycodone reward in both pain-free and chronic pain states.