Sounds, such as eating, chewing, or repeated pen clicking, can cause some people to have an emotional response called misophonia. Researchers at Newcastle University have discovered the physical basis for the disorder. The researchers used functional MRI to measure the brain activity of people with and without misophonia while they were listening to a range of sounds. The team revealed a physical difference in the frontal lobe between the cerebral hemispheres of people with misophonia – with higher myelination in the grey matter of ventromedial prefrontal cortex (vmPFC).The researchers report clear changes in the stucture of the brain’s fontal lobe in sufferers of the malady and also find changes in brain activity. The brain imaging revealed that people with the condition have an abnormality in the emotional control mechanism which causes their brains to go into overdrive on hearing trigger sounds.